Student Spotlight: Unraveling the links between smoking, genetics, and lung cancer from a global perspective

For her summer APE, MPH student Yuchan Cao investigated the patterns between smoking and cancer progression among lung cancer survivors in China.

Second-year MPH students at the Brown University School of Public Health are actively engaged in internships and projects through the Applied Practice Experience (APE) program. These opportunities lead them to diverse agencies and organizations in Rhode Island and across the globe. Our Student Spotlight series this summer follows their stories.

Nearly one-third of all the world’s smokers reside in China, where more than half of all adult men are tobacco smokers. MPH student Yuchan Cao has been intrigued by the complex interplay between genetic and environmental factors shaping China's consistently high smoking rate since her undergraduate studies in public health.

Tianjin Medical University Cancer Institute and Hospital
At Tianjin Medical University Cancer Institute and Hospital, Yuchan investigated patterns between smoking and cancer progression in China.

According to Yuchan, "the cultural, societal, and stress-related influences that lead to surging smoking prevalence in China provide a unique context for such research.”  

This summer, for her applied practice experience (APE), Yuchan took on a role investigating the patterns between smoking and cancer progression among lung cancer survivors in China. As a research assistant at Tianjin Medical University Cancer Institute and Hospital, her daily responsibilities involved managing, analyzing and interpreting the genetic data of Chinese lung cancer survivors. She deciphered genomic patterns to explore the link between smoking behavior and cancer susceptibility. 

"Our study aims to investigate the association between gene alterations and disease susceptibility, with a specific emphasis on lung cancer, by conducting a comparative analysis between individuals who smoke and those who do not," Yuchan said. 

“It has provided new insights into the multifaceted aspects of smoking behavior and its consequences, potentially contributing to more effective strategies for lung cancer prevention not only in China, but also in other regions facing similar challenges," she said.

Our study aims to investigate the association between gene alterations and disease susceptibility, with a specific emphasis on lung cancer, by conducting a comparative analysis between individuals who smoke and those who do not.

Yuchan Cao GS
 
smiling woman sitting

Yuchan decided to pursue her summer studies abroad to broaden her perspective from an international standpoint. When it comes to the complex health concerns encountered by communities throughout the globe, she believes that understanding these issues in various regions is crucial to developing therapies that are contextually appropriate, culturally sensitive, and internationally applicable.

Yuchan describes her APE as a rewarding experience: "The exchange of ideas and the shared commitment with a diverse team of researchers have been inspiring. I have also had eye-opening experiences seeing how public health interventions make a real-world impact and witnessing the strength of individuals facing health challenges.

"I hope to leverage the knowledge I’ve gained for future research projects and to work collaboratively with interdisciplinary teams to address challenges in understanding the interplay of behavioral risk factors and cancer, advocating for evidence-based interventions that can change lives."