$53.4M Grant to Brown, Hebrew SeniorLife to Enable Massive Expansion of Alzheimer’s Research

Projects will benefit from guidance from the collaboratory’s community of experts, who will assist with ethical concerns (such as how to secure informed consent from people living with dementia); technical support and generation of data on participant populations; statistics and project design; advice on how to measure patient- and caregiver-reported outcomes; dissemination of results and efforts to maximize the likelihood of implementation; partnering with health care systems interested in conducting trials; project administration; training for junior researchers; inclusion of and applicability to people of all backgrounds and cultures; and best practices to engage people interested in this work, including people living with dementia and their caregivers, health care systems and researchers.

Researchers at Brown and HSL have collaborated on aging research for nearly 40 years. Mor is renowned for his expertise in quality measurement and brings decades of experience running clinical trials focused on older adults within real-world health care systems, including skilled nursing centers. Mitchell, director of Palliative Care Research at the Marcus Institute and co-director of the Interventional Studies in Aging Center, has dedicated her career to research to improve the care of people living with dementia, particularly those in the later stages.

“It’s time for Alzheimer’s and other dementias to receive the same level of research focus and investment as cancer,” said Louis Woolf, HSL president and CEO. “We’re proud to collaborate with Brown University to address this national epidemic that affects not only patients, but their families and caregivers as well.”

Brown President Christina Paxson said the grant will complement efforts across the University to devise treatments and technologies to address a wide variety of brain-related diseases and injuries.

“Alzheimer’s and dementia remain among the most vexing neurodegenerative diseases both to researchers searching for solutions and to patients and family members,” Paxson said. “This grant will harness the collective power of leading-edge scholars at Brown, Hebrew SeniorLife and across the nation to advance care and make a positive real-world impact on the individuals most directly affected by these illnesses.”

Ideally, the yearlong pilot projects will originate with professionals within the affected health care systems, rather than only academic researchers, Mor and Mitchell said. This goal builds on the mission of the Center for Long-Term Care Quality and Innovation, which will lead administration of the grant and is based at Brown’s School of Public Health. The center focuses on partnering with innovators, including health care providers, to evaluate novel practices to improve the quality of care.

“This new grant harnesses the School of Public Health’s depth of expertise and collaborative strength to investigate pioneering interventions with the potential to transform the lives of those living with dementia, along with the lives of their families and caregivers,” said Bess Marcus, the school’s dean.

Mor said that the $53.4 million grant is one among many examples of how NIA is supporting research in recognition of the urgent and growing public health need to better care for the millions of American families who face dementia. The Alzheimer’s Association estimates that while more than 5 million Americans currently live with Alzheimer’s or a related dementia, the number is expected to double by 2050. The current annual cost of dementia care exceeds $226 million a year in the U.S. alone.

“The national discourse around Alzheimer’s and other dementias is growing louder by the day as the number of Americans suffering with this disease increases exponentially,” said Dr. Lewis Lipsitz, director of the Marcus Institute and chief academic officer. “The NIA IMPACT Collaboratory will provide the research infrastructure and community of experts needed to conduct realworld clinical trials that will meet this challenge head-on.”