Outside the Mainstream: Applying rigor to complementary & integrative approaches to health care

NCCIH funding will allow Brown researchers to evaluate complementary and integrative health interventions and produce a public-facing database to support rigorous systematic reviews.

Products and practices that are not yet a part of mainstream medical practice, like meditation, yoga, tai chi and acupuncture, fall under the umbrella of complementary and integrative health (CIH). Complementary, because these practices may be used in addition to standard medical care. Integrative, because mainstream and alternative practices are often blended. 

CIH approaches emphasize self-care, prevention and wellness, and are increasingly popular in the United States. According to the National Center for Complementary and Integrative Health of the National Institutes of Health, more than 30 percent of American adults and about 12 percent of children use health care approaches developed outside mainstream medicine. While early trials evaluating their benefits show promise, the scientific foundation for CIH interventions remains shaky at best.

Researchers from the Brown University School of Public Health, in collaboration with the University of Wisconsin-Madison, have been awarded a $3 million grant from the National Center for Complementary and Integrative Health to enhance the rigor, transparency and accuracy of CIH reviews, providing practitioners and the public with the highest-quality evidence upon which to develop the field. 

The funding supports the creation of the Mindfulness and Integrative Health Data Network (MINDNET), a comprehensive database dedicated to supporting systematic reviews and meta-analyses to evaluate CIH interventions such as mindfulness meditation, yoga and acupuncture.

MINDNET has the potential to influence the field significantly, akin to how similar datasets have revolutionized psychotherapy research.

Shufang Sun, PhD Assistant professor of behavioral and social sciences
 
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Led by Shufang Sun, assistant professor of behavioral and social sciences, Eric Loucks, associate professor of epidemiology, medicine and behavioral and social sciences, and Simon Goldberg, associate professor of counseling psychology at the University of Wisconsin-Madison, MINDNET seeks to enhance the foundation and application of CIH practices through rigorous evidence synthesis.

There is an increasing number of randomized controlled trials evaluating the benefits of CIH interventions across a range of psychological and physical conditions. Some studies indicate that mindfulness interventions can effectively reduce stress, for instance, while mindfulness-based cognitive therapy has demonstrated efficacy in helping to treat depression. 

Yet, the field faces several challenges, including methodological limitations in current clinical trials and reviews, insufficient training and resources for scientists conducting these reviews, and the need for rigorously conducted systematic reviews and meta-analyses to effectively synthesize the growing body of clinical trial data.

To address these concerns, researchers are establishing a process for identifying and coding outcomes of randomized controlled trials within key areas of CIH, with the goal of updating this database regularly and making it accessible through a public website. They are also working to fill educational gaps by offering resources and training for emerging scholars in order to elevate the reliability of CIH research.

“ I'm highly enthusiastic about MINDNET due to the potential it has to address the criticisms regarding the scientific rigor of clinical trials in the CIH field. ”

Shufang Sun, PhD Assistant professor of behavioral and social sciences

“One of the primary goals of MINDNET is to enhance rigor and transparency, produce high-quality reviews that offer the most accurate evidence to the public and the field, employing state-of-the-art scientific practices,” Sun said. “By collaborating with researchers and utilizing comprehensive meta-analysis datasets, MINDNET has the potential to influence the field significantly, akin to how similar datasets have revolutionized psychotherapy research.”

Sun adds that since review literature can drive policy and impact health care access and insurance coverage, improving the review process will facilitate evidence-based policymaking for CIH interventions.

Looking ahead, the research team plans to build a data repository system and collaborate with CIH experts and scientists in this process. The sum of these efforts are expected to contribute to the field’s credibility, paving the way for the integration of CIH into mainstream health care.

“I'm highly enthusiastic about MINDNET due to the potential it has to address the criticisms regarding the scientific rigor of clinical trials in the CIH field, provide nuanced and rigorous evidence review and inform future designs of clinical trials,”  Sun said.